Seattle Seahawks vs. Detroit Lions

2. Can a rushing attack keep rolling?

Detroit's passing attack hasn't quite clicked this season, although it ranks seventh in the NFL in passing tonight. However, Detroit's ground game averaged 163 rushing yards per game through the first three weeks of the season and they had a 188-yard performance on the ground in a win over Arizona last week. Detroit has gained at least 4.0 yards on 53 of its 101 rushing attempts this season, the third-best rate in the league.

Seattle ranks 15th in the NFL against the run, allowing 116 yards on the ground per game. The Lions are at their best offensively when they can set the pace with their running game and use the passing attack as a complement. Look for them to establish the run early and often tonight.

3. Replace defensive starter

Detroit lost defensive end Marcus Davenport for the remainder of the season and SAM linebacker Derrick Barnes for the foreseeable future. Davenport has been a productive player through the first three weeks for the Lions' defense, which ranks second in the NFL in QB hits (15) and top 10 in total pressures (57). Third-year defensive lineman Josh Paschal is expected to get the bulk of the snaps in Davenport's absence, although the Lions have the option of subbing various players opposite Aidan Hutchinson. It's important that the Lions perform from there, otherwise teams will devote more and more resources to slowing down Hutchinson on the other side.

As for replacing Barnes, Glenn said he has a lot of confidence in the depth at linebacker, probably more than any other position group in his defense.

“We have a number of guys in that linebacker room that would love to play that role,” Glenn said this week. “And I've said this every week: This is a space that I have a lot of respect for the way they work. I have a lot of respect for the friendship and the closeness that they have in this room, and I have a lot of respect for the diversity that we have in this room.”