SMU at Louisville odds, picks and predictions

The number 22 Louisville Cardinals (3-1, 0-0 ACC) welcome the SMU Mustangs (4-1, 1-0) at L&N Federal Credit Union Stadium on Saturday. Kickoff is scheduled for noon ET (ESPN). Let's analyze the 24/7 college football odds from BetMGM Sportsbook SMU vs. Louisville Opportunitiesand make our college football picks and predictions.

Louisville is No. 22 in the US LBM Coaches Survey. The Cardinals defeated Austin Peay 62-0 to start the season and won each of their first three games by 12 or more points. Louisville lost its only competitive game of the season 31-24 to the No. 13 Notre Dame Fighting Irish in Week 5 and finished as a 6.5-point underdog.

SMU defeated the Florida State Seminoles 41-26 in Week 5, making them a 6-point home favorite. The Mustangs have won two straight, scoring a total of 108 points in the victories. Their only loss of the season was an 18-15 home loss to No. 19 BYU in which they were not considered 12.5-point favorites. SMU is 3-2 ATS this season and 1-0 ATS in conference play.

– Rankings: US LBM Coaches Survey conducted by the American Football Coaches Association and USA TODAY Sports

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SMU at Louisville odds

Powered by BetMGM Sportsbook; Visit the USA TODAY sports scores and sports betting hub for a complete list of college football odds. The lines were last updated on Friday at 4:29 p.m. ET.

• Moneyline (ML): SMU +200 (bet $100 to win $200) | Louisville -250 (bet $250 to win $100)
• Against the Spread (ATS): SMU +6.5 (-105) | Louisville -6.5 (-115)
• Over/Under (O/U): 56.5 (O: -110 | U: -110)

SMU at Louisville tips and predictions

forecast

Louisville 31, SMU 27

Money line

HAPPEN.

There is no good value on the moneyline. While the Cardinals (-250) should be ahead, they are too expensive to play straight up. Avoid a moneyline game and pay attention to the spread to find value.

Against the spread

BET SMU +6.5 (-105).

The Cardinals don't have a player with more than 300 rushing yards in four games. They prefer to attack opponents from the air and SMU allows the 11th lowest completion rate of opponents at 53.3%. The Cardinals might have a hard time consistently moving the ball this way.

Louisville also suffered a loss in its first game with a lead of 7 points or fewer. The Mustangs have exceeded weather expectations of late, winning 26 times in Week 5 and 24 in Week 4, finishing as 6-point favorites and 1.5-point underdogs, respectively.

Expect this trend to continue and decline SMU +6.5 (-105).

Over/Under

BET OVER 56.5 (-110).

Both teams love moving the ball and scoring points. SMU has scored at least 42 points in 3 games and scored at least 29 points in 4 of 5. The Mustangs are 3-2 O/U and 2-0 O/U in their last two games. The Cardinals have scored at least 31 points in 3 of 4 games and also walked in 3 of 4 overs.

Louisville allowed 31 points to Notre Dame and 19 the week before to Georgia Tech. It has a competent defense, but that side of the ball has been the team's biggest weakness of late. Combine everything and take it with you OVER 56.5 (-110).

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